By Jonathan Black
Normal CONSIDERATIONSBiocompatibility: Definitions and concerns creation organic functionality Consensus Definitions dialogue The self-discipline of Biomaterials Afterword: Paradigmatic Shift creation to the organic setting normal concerns comparability of exterior and inner ConditionsProblems in Definition of the organic EnvironmentElements of the organic setting Implant lifestyles History Preimplantation dealing with results fabric reaction: functionality ANDDEGRADATION OF MATERIALSIN VIVOSwelling and Leaching advent Fick's legislation of DiffusionAbsorption Examples of Undesi. Read more...
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Additional resources for Biological Performance of Materials : Fundamentals of Biocompatibility
4 Examples of Undesirable Absorption One special case will be examined: diffusional pickup by a sphere in a medium of constant concentration. The application is the problem of the “variant” heart valve poppet. 2). This was an early and usually successful design for human aortic valve replacement; however, for a small percentage of patients, the ball jammed in the cage or, in some cases, the ball actually escaped. Discoloration of such recovered balls, termed “variant,” suggested that some material had been absorbed, leading to swelling.
Oxidation or other attack may occur during preoperative storage. Materials may be picked up from packaging used for storage or during sterilization. Contaminants may be transferred from surgical instruments. For this reason, experimental studies of biological performance should include surface characterization of actual implant specimens selected from the full group fabricated in a particular study in the condition just before surgical insertion. Furthermore, care should be taken when materials are incorporated into devices for clinical trials and use, to see that the surface conditions are the same as those found during earlier developmental studies.
4(4), 1097, 1973. 1 and is one-tenth of the maximum value reported for the heart valve poppets. 2. 2, with an attempt to estimate mean lipid values of the failed implants within 12-month intervals, suggests another possible conclusion concerning the relationship between lipid content and device fracture. It is possible that there are two populations of failed implants: those that take up lipid with abnormal rapidity (represented by the failures in the first 12-month period) and those that take it up quite slowly (represented by the later failures).