Basic and Clinical Endocrinology by Francis S. Greenspan, David G. Gardner

By Francis S. Greenspan, David G. Gardner

The best-selling reference in endocrinology! Authoritative, concise, and present, this "all-in-one" textual content specializes in the pathophysiology, analysis, and remedy of endocrine issues. Written by means of well-known gurus and that includes greater than 350 two-color illustrations, the 7th variation has been up to date to mirror the most recent in diagnostic trying out and molecular biology in addition to new ways to clinical administration.

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Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, et al. A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2. Am J Hum Genet 2007;81:673–83. 35. Taylor SI, Cama A, Accili D, Barbetti F, Quon MJ, la Luz Sierra de M, et al. Mutations in the insulin receptor gene. Endocr Rev 1992;13(3):566–95. 36. Musso C, Cochran E, Moran SA, Skarulis MC, Oral EA, Taylor S, et al. Clinical course of genetic diseases of the insulin receptor (type A and Rabson-Mendenhall syndromes): a 30-year prospective.

An ideal operational definition for neonatal hypoglycemia would be defined as the blood glucose concentration below which value significant morbidity (especially neurologic sequelae) would be seen and therefore at which intervention should be undertaken. 5 It should be also borne in mind that hypoglycemia on the day of birth or during the first few days of life may not necessarily have a pathological etiology. The transition between • Glycogenolysis: Breakdown of hepatic glycogen. This suffices to maintain euglycemia from several hours in a child to up to 12 h in an adult).

1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy Cohort. Diabetes Care 2014;37:1230–6. 18. Steele AM, Shields BM, Wensley KJ, Colclough K, Ellard S, Hattersley AT. Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia. JAMA 2014;311(3):279–86. 19. Stride A, Shields B, Gill-Carey O, Chakera AJ, Colclough K, Ellard S, et al. Cross-sectional and longitudinal studies suggest pharmacological treatment used in patients with glucokinase mutations does not alter glycaemia.

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Basic and Clinical Endocrinology by Francis S. Greenspan, David G. Gardner
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