Artificial Enzymes by Ronald Breslow

By Ronald Breslow

This primary publication in this attention-grabbing subject is edited by way of one among trendy most famed and the world over revered natural chemists, well known for his pioneering synthesis of the cyclopropenyl cation.
For his half, Ronald Breslow has introduced jointly major scientists during this increasing zone to supply a unique evaluate of protein-, cyclodextrin-, steel- and porphyrin-based man made enzymes in addition to enzyme-like polymers and dendrimers.
A needs to for all scientists drawn to this rising field.

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Initially, we prepared b-cyclodextrin dimers 113–116 [183], which were examined for substrate binding with two p-t-butylphenyl groups. With ester 117 and cyclopropene 118 we saw binding constants as high as 108 M–1. This is double the free energy of binding of simple p-t-butylphenyl groups into a single cyclodextrin – binding constants are generally about 104 M–1 – so the free energies of binding were additive with substrates that could fit well. Even stronger dimeric binding, due to the entropy advantages of chelate binding, was seen with cyclodextrin dimer 119, which was doubly linked, restricting its rotational freedom [184].

Breslow, B. Zhang, J. Am. Chem. Soc. 1992, 114, 5882–5883. B. Zhang, R. Breslow, J. Am. Chem. Soc. 1997, 119, 1676–1681. R. Breslow, S. Belvedere, L. Gershell, D. Leung, Pure Appl. Chem. 2000, 72, 333–342. R. Breslow, S. Belvedere, L. Gershell, Helv. Chim. Acta 2000, 83, 1685–1692. J. Yan, R. Breslow, Tetrahedron Lett. 2000, 41, 2059–2062. R. Breslow, N. 1999, 40, 3335–3338. S. Gellman, R. Petter, R. Breslow, J. Am. Chem. , 1986, 108, 2388–2394. R. Breslow, S. Singh, Bioorg. Chem. 1988, 16, 408–417.

B. Siegel, R. Breslow, J. Am. Chem. Soc. 1975, 97, 6869–6870. J. le Noble, S. Srivastava, R. Breslow, G. Trainor, J. Am. Chem. Soc. 1983, 105, 2745–2748. -J. Thiem, M. Brandl, R. Breslow, J. Am. Chem. Soc. 1988, 110, 8612–8616. R. Breslow, S. Chung, Tetrahedron Lett. 1990, 31, 631–634. B. Siegel, A. Pinter, R. Breslow, J. Am. Chem. Soc. 1977, 99, 2309–2312. R. Breslow, Chem. & Eng. News, September 8, 2003, 86. R. Breslow, D. Wernick, J. Am. Chem. Soc. 1976, 98, 259–261. R. Breslow, D. L. Wernick, Proc.

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Artificial Enzymes by Ronald Breslow
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