Aldosterone - A Medical Dictionary, Bibliography, and by Icon Health Publications

By Icon Health Publications

This can be a 3-in-1 reference ebook. It provides an entire clinical dictionary masking 1000's of phrases and expressions in terms of aldosterone. It additionally offers large lists of bibliographic citations. eventually, it offers info to clients on how you can replace their wisdom utilizing quite a few web assets. The booklet is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with examine devoted to aldosterone. in case your time is effective, this booklet is for you. First, you won't waste time looking the web whereas lacking loads of correct info. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing hundreds and hundreds of websites.

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Additional info for Aldosterone - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

In the present proposal, we will study the usefulness of two drugs that inhibit ENaC activity, spironolactone, an antagonist of aldosterone, and amiloride, a direct inhibitor of ENaC, in blacks with low-renin hypertension who have shown resistance to treatment. We will follow a simple protocol wherein we will study patients taking an optimal regimen of antihypertensive medication including a full dose of diuretic but in whom a normal blood pressure has not been achieved. The patients will be randomized to either spironolactone 25 mg per day, amiloride 10 mg per day, the combination of spironolactone 25 mg and amiloride 10 mg per day, or placebo for 9 weeks.

Subaims will test effects of in vivo AT1R blockade or placebo 3A. on hemodynamic and 3B. on AnglI contractile signaling via classic and EGFR-transactivation routes (using renal vascular reactivity and activated vs total signaling protein abundance in fresh vascular/cortical tissues). Studies address a worldwide health risk, test interventions (weight control/AT1R block) of potential clinical value, and impact the current pediatric practice of promoting catch-up growth in low-birth-wt infants. ; James T.

22 Aldosterone cardiac fibroblast is determined by the combinatorial actions of several key proinflammatory cytokines and fibrogenic growth factors. We propose further that this phenotype represents a fundamental change in the transcriptional program of the cell, resulting from interactions of the signaling cascade(s) and downstream nuclear regulators initiated by these agonists. To elucidate the signaling mechanisms which underlie these phenotypic endpoints, the following specific aims are identified: Specific Aim 1 will determine the signaling mechanisms of cytokine and growth factor regulation of fibroblast proliferation; Specific Aim 2 will investigate cytokine and growth factor regulation of fibroblast migration and cytoskeletal organization; Specific Aim 3 will determine signaling mechanisms of cytokine and growth factor regulation of extracellular matrix metabolism; and Specific Aim 4 will define cytokine regulation of autocrine-paracrine mediators of fibrosis; namely, the Renin-Angiotensin and TGFbeta systems.

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Aldosterone - A Medical Dictionary, Bibliography, and by Icon Health Publications
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