Advances in Protein Chemistry, 4 by C B Anfinsen

By C B Anfinsen


Show description

Read or Download Advances in Protein Chemistry, 4 PDF

Similar clinical chemistry books

Organosilicon chemistry II: from molecules to materials

Organosilicon Chemistry at its most sensible. .. Like its highly winning predecessor, this quantity provides the newest advancements in a speedily constructing box of business and educational study. Written by way of major specialists, it's a distinct instruction manual for each scientist eager about organosilicon compounds and their functions.

Genetics of Asthma and Chronic Obstructive Pulmonary Disease (Lung Biology in Health and Disease 218)

Responding to the sizeable progress that has taken position within the box over the last decade, this reference offers an in-depth review of present concept at the genetics and genomics of bronchial asthma and COPD on the subject of their pathogenesis and therapy. With contributions through an esteemed workforce of foreign professionals at the subject, this resource spans the newest advancements within the usage of microarray concepts, linkage and organization stories, mapping concepts, comparative genetics, microarray ideas, proteomics, and pharmacogenomics.

Additional resources for Advances in Protein Chemistry, 4

Example text

The amorphous ring, which is shown by both gel and solution, is considered to be the result of diffraction by the disordered portions of the chains. When a gel is stretched, the bundles or crystallites are partly aligned in the direction of stretch, accounting for the resolution of the sharp rings into a fiber pattern. According to this view, the network is formed by partial crystallization of certain regions of the chain; the evolution of heat and contraction in volume which FIG. 10. Schematic diagram of net- accompany gelation are analogous work formed by crystallites.

The high electrostatic repulsion is probably even more important than the low dielectric constant in keeping the denatured protein in solution. When the magnitude of the coulombic repulsion is diminished by presence of neutral salt, association may occur here and there between the polypeptide chains, leading to formation of a gel network. With a higher proportion of salt, gelation occurs before the denaturation process has proceeded far enough t o build up a very high concentration 50 JOHN D. FERRY of free chains, and, in accordance with the principles already outlined, a coarse, opaque gel is formed.

Rigidity and Other Mechanical Properties. The modulus of rigidity, G, the most characteristic gel property, and the related modulus of elasticity (very nearly equal to 3 G ) , can be calculated from measurements of the deformation of a gel in shear and in extension, respectively, under PROTEIN GELS 29 known stress. Blocks of material may be bent or stretched (Leick, 1904); for a weaker system, which deforms under its own weight, it is convenient to subject the material to torsion between two concentric cylinders, the outer of which serves as a container (Hatschek and Jane, 1926).

Download PDF sample

Advances in Protein Chemistry, 4 by C B Anfinsen
Rated 4.80 of 5 – based on 47 votes