2011-2012 Basic and Clinical Science Course, Section 4: by Robert H. Rosa Jr., MD

By Robert H. Rosa Jr., MD

This quantity is split into elements: half I, Ophthalmic Pathology; and half II, Intraocular Tumors: scientific points. half I makes use of a hierarchy that strikes from normal to express to assist derive a differential analysis for a selected tissue. half II is a compilation of chosen medical points of significance to the overall ophthalmologist. Following half II are the yankee Joint Committee on melanoma 2010 staging varieties for ocular and adnexal tumors. This revised textual content includes various new pathologic and scientific pictures. significant revision 2011-2012.

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Additional info for 2011-2012 Basic and Clinical Science Course, Section 4: Ophthalmic Pathology and Intraocular Tumors (Basic & Clinical Science Course)

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The color product of the ch romogens gene rally used in ophthalmic pathology is brown or red in tissue sections, depending on the chromogen selected for use (Fig 4-2). Red chromogen is especially helpful in working with ocular pigmented tissues and melanomas, because it differs from the brown melanin pigment (see Fig 4-7) . The precise cell or cells that display the speCific antigen can be identified using these methods. Many antibodies are used routinely for diagnosis, treatment, and prognosis: cytokeratins for lesions composed of epithelial cells (adenoma, carcinoma) desmin , myoglobin, or actin for lesions with smooth muscle or skeletal muscle fea - tures (leiomyoma, rhabdomyosarcoma) 5-100 protein for lesions of neuroectodermal origin (schwannoma, neurofibroma, melanoma) HMB-45 and Melan A for melanocytic lesions (nevus, melanoma) 33 34 • Ophthalmi c Pathology and Intraocul ar Tumors Table 4-' Checklist for Requesting an Ophthalmic Patholog ic Consultation Routin e Specime ns (cornea, con juncti va, eye li d lesions) 1.

Courtesy of Hans E. J a shadow (Fig 3-2A). The shadow can be outl ined with a marking pencil on the sclera (Fig 3-2B). This outline can then be used to guide the gross dissection of the globe so that the center of th e section will incl ude the maximum extent of th e area of interest (Figs 3-2C to 3-2£). Gross Dissection A globe is opened so as to display as much of the pathologic change as possible on a Single slide. The majority of eyes are cut so that the pupil and optic nerve are present in the same section, the PO section .

See BCSC Section 2, Fundamentals and Principles of Ophthalmology, and Section 8, External Disease and Cornea, for further discussion . Congenital Anomalies Choristomas A choristoma is a benign, congenital proliferation of histologically mature tissue elements not normally present at the site of occurrence. This heterotopic congenital lesion results from normal tissue migrating to or remaining in an abnormal location during embryogenesis (hence the deri vatio n from the Greek word for "separated mass").

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2011-2012 Basic and Clinical Science Course, Section 4: by Robert H. Rosa Jr., MD
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