2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD

By Ramana S. Moorthy, MD

A dialogue of the scientific method of uveitis results in largely rewritten chapters on noninfectious (autoimmune) and infectious sorts of uveitis. additionally lined are endophthalmitis, masquerade syndromes, and problems of uveitis. A dialogue on ocular involvement in AIDS has been up-to-date. The part on immunology describes the human immune reaction in phrases that make it hugely available to readers.

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Additional resources for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)

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28 . Intraocular Inflammation and Uveitis Immunologic Microenvironments Regional immunologic differences occur because different tissue sites are composed of different immunologic microenvironments. The concept of immunologic microenvironment incorporates a broad range of anatomical and physiologic differences among tissues or organs that regulate the immune response: . the presence of well-formed lymphatics · ·. · . specialized immunologic structures (Peyer patches or conjunctival follicles) blood-tissue barriers to macromolecules or cell migration type of resident APC constitutive synthesis of immunoregulatory cytokines or molecules by the parenchymal cell types many other factors The analysis of immunologic microenvironments has become important for understanding the immunology of transplantation, infection, and autoimmunity for gene therapy or many organ systems.

The term paratope refers to the epitope-specific binding site on the Fab (fragment, antigen-binding) portion of the antibody. In addition, such a protein often can be enzymatically digested into many different peptide fragments, some of which contain molecular information to serve as antigenic epitopes for T-lymphocyte recognition and some of which are not recognized at all by the immune system. Afferent lymphatic channels Also simply called lymphatics, afferent lymphatic channels are veinlike structures that drain extracellular fluid (ie, lymph) from a site into a regional node.

The initial exposure, often called priming or activation, occurring in the lymph node 2. a second exposure, often called restimulation, happening in the peripheral tissue in which the initial antigen contact occurred This second exposure is usually necessary to fully exploit the effector mechanism within a local tissue. All of these effector mechanisms are described in more detail in Chapter 4. Subsets of effector T lymphocytes can be distinguished into 2 main types by functional differences in experimental assays or by differences in cell surface molecules (Fig 2-5).

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2008-2009 Basic and Clinical Science Course: Section 9: by Ramana S. Moorthy, MD
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